Antibody

Antibody

Prostate Cancer Antibody – Promising Treatment For Your Cancer

Posted on April 9, 2018 in Uncategorized

A number of researchers have revealed an antibody which will bond with prostate cancer tissue and instigate direct cell death while injected into mice. The discovery would nearly be a treatment to cancer of prostate if outcomes carry over to humans.

It is one of the principal diseases frightening men nowadays. The cancer is #2 on the listing of most widespread cancers in men. More than the past 150 years lots of various treatments have been developed as part of research for prostate cancer treatment.

The study published in PNAS {the Proceedings of the National Academy of Science} stated that the antibody, called F77, was discovered to bond more readily with tissues and cells of cancerous prostate than with benign tissue and cells, and to help the death of cancerous tissue.

Even so, the study showed that it did not be intended for normal tissue or tumor tissues in other areas of the body including the colon, kidney, pancreas, skin cervix, lung, or bladder.

Researchers wrote the antibody “proves promising potential for diagnosis and treatment of the cancer, particularly for androgen-independent metastatic prostate cancer,” which frequently extends to the bones and is not easy to treat.

Antibodies are also already being employed to deal with diseases like lymphoma and breast cancer. It is said that until now there has been no successful antibody therapy for cancer of prostate. However, any research team has produced an antibody named F77 which looks so potential. In spite of the research being at a very early step, it brings up the hope of an effectual treatment for advanced prostate cancer.

What are Antibodies

Posted on April 3, 2018 in Uncategorized

Antibodies, also called immunoglobulins are large y-shaped proteins which function to identify and help remove foreign antigens such as viruses and bacteria.

In mammals there are five main types of antibodies including: IgA, IgD, IgE, IgG, and IgM. There are 4 IgG and 2 IgA subtypes present in humans.

Antibodies are created by plasma cells which are derived from the B-cells in the immune system. Due to the fact that antibodies exist freely in the bloodstream or bound to cell membranes, they are said to be part of the humoral immune system.
Every different antibody recognizes a specific foreign antigen. This is because the two tips of its “Y” are different to each antibody are allow different antibodies to bind to different foreign antigens. When the antibody binds to a bacteria, it tags the microbe or virus for attack by the immune system such as killer T-cells. Sometimes, antibodies can directly neutralize the foreign body. The production of antibodies by B-cells is the main function of the humoral immune system.

Autoimmune disorders can usually be traced to antibodies which bind the body’s own proteins or epitopes, and these types of antibodies can be detected through serological blood tests. Due to the amazing specificity of antibodies, they have some important practical applications in both medicine for the detection of HIV and other viruses in blood, and in research to purify and detect proteins in the study of molecular biology. For example, currently medicine is using biotechnologically designed monoclonal antibodies which work as an antibody therapy. These methods are being employed recently and are the result of numerous clinical trials in a number of diseases including cancer, and rheumatoid arthritis.

[Top]

BCL2 Antibody – Inducing Apoptosis

Posted on March 28, 2018 in Uncategorized

Bcl2 antibody – The Bcl2 gene plays an important role in a large assortment of cellular activities, in particular the regulation of cell death. This is facilitated by including or repressing apoptosis based on environmental stimuli.

Bcl2 plays an important role in the regulation of cell death, either inducing or repressing apoptosis based on environmental effects. Consequently, because of the apoptotic regulation, Bcl2 plays an important role in cancer research, cancer diagnostics and regulation of immune cells. BCL2 gene damage has been identified as a cause of a number of cancers, including melanoma, breast cancer, prostate cancer, lung cancer and certain types of leukemia.

A damaged BCL2 gene is also the cause of resistance to a number of cancer treatments. Therefore, Bcl2 antibody can be used in immunohistochemistry to distinguish cells that contain the target Bcl2 antigen. The antibodies usually react inside healthy tissues with B cells in the mantle zone, in addition to some T cells. In cancer tissues there is a substantial increase in the number of positive cells in follicular lymphoma and several other forms of cancer. On occasions, the presence or absence of Bcl2 staining in biopsies could perhaps be vital for the patient’s prognosis or the probability of a relapse.

The primary function of Bcl2 is to induce apoptosis; it does so by inducing the release of cytochrome c to begin the apoptotic cascade. Therefore, malfunctions in whichever of the Bcl2 gene or in the apoptotic cascade may possibly lead to damaged cells by missing the signal to shut down. Cancer possibly occurs as the result of an imbalance between cell death and cell growth. Anti-apoptotic protein expression and under expression of pro-apoptotic genes can, and often do, result in the lack of cell death that is characteristic of cancer. Apoptosis is very important in immune system regulation, destroying immune cells that recognize self-antigen, possibly aiding in the prevention of harmful autoimmune diseases such as Lupus and Type 1 diabetes.

The Bcl2 antibody can be used in IHC-P (immunohistochemistry) to distinguish cells that contain the target Bcl2 antigen. The antibodies usually react inside healthy tissues with B cells in the mantle zone, in addition to some T cells. Conversely, in cancer tissues there is a substantial increase in the number of positive cells in follicular lymphoma and several other forms of cancer. On occasions, the presence or absence of Bcl2 staining in biopsies could perhaps be vital for the patient’s prognosis or the probability of a relapse.

In a trial experiment the expression of Bcl2 antibody in skeletal muscles could potentially play a role on surviving muscle fibers. As the control muscles was generally positive in the nuclear membrane and cytoplasm in type 2B fibers. This experiment was conducted by using 178 biopsied human pathologic muscles and 10 control muscles by the ABC process.

The antibody can be tested on a range of applications, for instance WB (western blot), IHC-P (immunohistochemistry), and P-ELISA. This is used to test the antibody on a large assortment of model species such as mouse, rat, cow, dog, chicken, pig, and Human.

[Top]