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Month: September 2018

Beyond The Obvious: Game-Changing Innovation by Phil McKinney – Neutralizing Corporate Antibodies

Posted on September 22, 2018 in Uncategorized

“Innovation” is one of the biggest buzzwords of twenty-first century business vernacular. Phil McKinney, author of the new book, “Beyond The Obvious: Killer Questions That Spark Game-Changing Innovation,” presents an in-depth account of what it takes to be truly innovative. He admits that innovation is hard work; and no organization gets it 100 percent right. But, with a disciplined approach, anyone can become more innovative.

McKinney provides a set of Killer Questions that any company can use to hone their innovative mindset. Before you can use those questions, he says you must address your industry and company assumptions, manage the inevitable jolts and neutralize the corporate antibodies. Here, the focus is corporate antibodies.

Corporate antibodies are analogous to the antibodies in our immune system, which attack and destroy possibly harmful foreign objects. “Antibodies” in your organization identify and neutralize forces that threaten to destabilize a company. Much like an organism’s antibodies can damage the very thing they seek to protect (i.e. when they cause the body to reject a transplanted organ); corporate antibodies can stunt a company’s growth by squelching fresh ideas and badly needed unconventional thinkers. McKinney defines four types of corporate antibodies:

1. The Ego Response.

  • “Oh, I already thought of that a long time ago.”
  • “I have something better.”

To get their support, you need to appeal to their ego and solidify their need for personal validation. The key is to show you’re not challenging them. Put their suggestions to work in your idea and pitch. Acknowledge that those suggestions came from them. You’re now giving them a sense of ownership in the concept; and they’ll be more inclined to support your idea.

2. The Fatigued Response.

  • “You’ll never get approval.”
  • “We tried that before.”
  • “It won’t fit our operation.”

This corporate antibody may have pitched ideas of their own, only to have them dismissed. They’re burned out and only half listen to new ideas. As you describe your idea, his biases automatically appear, drawing connections between your new concept and old ideas that didn’t work.

You need to draw out their biases, understand what old experiences they remember; and devise a way to demonstrate that those things aren’t applicable to your new idea. Keep the dialogue going. Ask questions and engage them in your idea by asking their opinions.

Every question you can ask draws the corporate antibody closer to supporting you. They may not realize it, but they’re slowly becoming invested in your idea. You’ll discover an opportunity for a direct question about the viability of your idea. One acknowledgement from them that there is an opportunity that didn’t exist before and you’re ally-bound.

3. The No-Risk Response.

  • “Not enough return on investment.”
  • “We can’t afford that.”

This corporate antibody response understands that doing nothing might not advance their career or company status, but it also avoids any downside risks. “No-risk” is stagnancy that can be hard to diffuse.

The most effective way to gain support is to demonstrate that there is less risk than they think. Explain that supporting the first step of your idea will be low-risk, low-cost and doesn’t commit them to moving on to a bigger investment. Determine how you get people comfortable with risk. Present your concept in small steps. Asking for a few thousand dollars to prove that your customer really needs the product will garner a yes faster than asking for the full budget (and full risk) all at once.

McKinney highlights a subtle truth about innovation. “Sometimes there is no other way around a “no-risk” corporate antibody than a slightly cunning interpretation of the rules, or selective hearing when you’re told no.” He doesn’t advocate lying or deceit, but he says, you’ll find more people who feel empowered to say no than people who feel they’re empowered to say yes. “Don’t lie, but don’t always wait for permission, either. If you believe in your idea and you’re willing to take a risk, put your plan in motion. You can always ask for forgiveness later.”

4. The Comfort Response.

  • “We’ve always done it this way.”
  • “Our customers like it this way.”
  • “Don’t rock the boat.”

Corporate antibodies that stubbornly believe change isn’t desirable or feasible may be confined to outdated thinking about what success looks like. It’s important to understand that while your core mission may stay the same, the way you define success in achieving it may change.

McKinney concludes that corporate antibodies believe that they’re working in the best interest of their employer and customers. They believe they’re serving as a gatekeeper- the last line of defense against people or ideas that might damage the organization. To become allies, you need to convince them that you aren’t a threat and that your idea actually aligns with, and complements their ideals.

He also says “nearly all great ideas require nerve, vision, and guts to get in motion.” If you can’t develop the skills to work around your in-house adversaries, you’ll struggle to ever get your ideas and innovations launched.

Lastly, if you’re constantly shot down by corporate antibodies, you’ll need to decide if being held back by these people is acceptable, or, do you make a bold move to an organization that will support your ideas.

For a list of the World’s 50 Most Innovative Companies, as ranked by Fast Company, visit: http://www.fastcompany.com/most-innovative-companies/2012/full-list.

Custom Antibody Development – An Important Invention

Posted on September 15, 2018 in Uncategorized

We all are aware of the word Antibody very well. Antibodies are those things that protect us from various Infections. These are large Protein molecules white cells.

Antibodies produced by the immune system in the response to the presence of antigens in the human body. These antigens can be Bacteria, Bacterial Toxins, Viruses, or other Cells or Protein. Such antigens are capable of disrupting the body’s process.

Human body contains hundreds of thousands of different white blood cells called “B lymphocytes”, each capable of producing one type of antibody and each bearing sites on its membrane that will bind with a specific antigen. When such a process starts, It trigger the B lymphocytes to reproduce itself formatting a clone that manufactures a big amount of its antibody.

There are five different type of antibodies present in human serum and tissues. These antibody classes are IgM, IgA, IgG, IgE, and IgD. There are other four classes of IgG to make things difficult to understand. IgM is the first antibody to be made in facing new antigens. IgG is the most prevalent antibody serum. IgA is mainly found on the surface of molecules and in secretions like tears, saliva etc. IgE is present in low level in serum. IgD is found in the surface of immature in cell, where it plays a role in B cell maturation.

In Short Antibodies are very important part of white cell which protect human body from damage done by various antigens.

There are so many agencies across globe which is involved in custom antibody production. It is a work which requires great research and special environment. Custom antibody development is one of the most important inventions of Bio-science industries.

Type 2 Diabetes – Can Low Levels of Antibodies Contribute to the Development of Diabetes?

Posted on September 7, 2018 in Uncategorized

Scientists at Guandong Medical University and several other research institutions in China and Scotland found low levels of certain types of antibodies in people who had been diagnosed with Type 2 diabetes. These antibodies stop inflammation, which has a known link to insulin resistance, the cause of Type 2 diabetes.

In November of 2017, the Journal of Inflammation, (London), reported on a study that looked at antibodies to inflammatory molecules in people with Type 2 diabetes. Women had decreased levels of the antibodies called anti-IL6 IgG and anti-IL8 IgG. Both molecules are inflammatory, as is anti-TNF-ALPHA IgG, which was seen in low levels in men. The participants were then given blood sugar lowering drugs for 6 months. HbA1c levels were found to be…

  • lowest in those diabetics with the highest levels of anti-ILALPHA IgG and
  • highest in those with low levels of the antibodies,

although the differences were not statistically significant.

From this information the researchers concluded deficiencies of antibodies to inflammatory molecules probably raises the risk for the development of Type 2 diabetes.

Antibodies are proteins that attach themselves to molecules known as antigens. We usually think of antibodies as connecting themselves to alien organisms, such as bacteria and viruses to enable white blood cells to engulf and kill the invaders.

Inflammation is part of the immune response, but it must fade away after the invaders have been vanquished. The role of antibodies to inflammatory molecules is to stop inflammation.

Antibodies are also known as immunoglobulins, and they are composed of three protein chains held together in a Y shape. Five types of antibody are classified according to their species of chains. The chains include…

  • IgG,
  • IgM,
  • IgA,
  • IgE, and
  • IgD.

Inflammation is defined by the five conditions it causes…

  • heat,
  • redness,
  • pain,
  • loss of function, and
  • swelling.

Inflammation in the body is named for the inflamed organ plus the ending “itis.” For instance, inflammation of the skin is called dermatitis, “derma” for skin, and “itis” for inflammation.

Two main classes of drugs are used for fighting inflammation…

  • cortisone which resembles a body hormone, and
  • non-steroidal anti-inflammatory drugs (NSAIDs) include medications such as aspirin, Tylenol, and Motrin.

Cortisone is a steroid, which works against inflammatory reactions by blocking white blood cells from going to the site where the inflammation takes place. (Not to be confused with steroids used illegally to boost athletic performance).

NSAIDs work against body molecules called prostaglandins, which are also pro-inflammatory.

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